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Welcome to, The Bleeding Information Source, an Internet site designed for physicians and other health care personnel who want information about bleeding, coagulation, and hemostasis, including therapeutic approaches.

Bleeding occurs when native hemostatic function is altered due to a variety of factors. Blood is normally prevented from leaking outside blood vessels through hemostatic mechanisms that include coagulation proteins, platelets, tissue factor, and vascular components. Tissue factor is a lipoprotein that is constitutively present on the membrane of certain cells. When it is exposed, it binds to Factor VII (one of the central coagulation factors) and activates the tissue factor dependent coagulation pathway. Factor VIIa plays a pivotal role in hemostasis and the response to bleeding (see

Therapeutic approaches to bleeding include transfusions, hemostatic agents, and/or correction of the underlying problem. Because of the pivotal role of hemostasis in surgery, critical care, trauma, perioperative medicine, and hematology, therapeutic approaches to treating bleeding and bleeding problems are important. Further, a broad spectrum of coagulation and platelet inhibitors have assumed a pivotal role in clinical medicine, yet at the same time present the potential for bleeding. This site provides links to the resources available regarding these important issues on the Internet.

This site is sponsored by, an Internet site dedicated to bringing useful information to physicians and other healthcare personnel. Be sure to visit to keep up on what is new and interesting in healthcare, and for other helpful information. Please contact us at if you have additional suggestions or comments.

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